Discover RINVOQ’s transformative power in managing ankylosing spondylitis. Understand AS causes and symptoms. Regain mobility and reduce pain.
What is Ankylosing Spondylitis?
Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints, which connect the spine to the pelvis.1 It is a type of inflammatory arthritis that belongs to a group of conditions known as spondyloarthritis. AS predominantly affects the axial skeleton, which includes the spine, pelvis, and rib cage. It can also affect other joints, such as the shoulders, hips, knees, and ankles, as well as entheses, where tendons and ligaments attach to bone.
AS is characterized by inflammation of the joints and entheses, leading to pain, stiffness, and reduced mobility. The inflammation can cause new bone formation, resulting in the fusion of vertebrae in the spine, a process known as ankylosis. This can lead to a hunched posture and reduced spinal flexibility. AS can also affect other organs and systems in the body, including the eyes, heart, lungs, and kidneys.
The exact cause of AS is unknown, but genetic factors, particularly the presence of the human leukocyte antigen (HLA)-B27 gene, are believed to play a significant role. AS is more common in men than women and typically begins between the ages of 20 and 40. Early diagnosis and appropriate treatment can help manage the symptoms of AS and prevent or slow the progression of the disease.
Discover the Causes of Ankylosing Spondylitis
The precise etiology of ankylosing spondylitis (AS) remains multifaceted and not fully understood. However, extensive research has identified several contributing factors, including genetic predisposition, immune system dysregulation, and environmental triggers.
Genetic factors play a pivotal role in the development of AS. The presence of the human leukocyte antigen (HLA)-B27 gene is strongly associated with an increased risk of AS. Approximately 90% of individuals with AS carry this gene, although it is important to note that not all individuals with the HLA-B27 gene will develop the condition.
Immune system dysregulation is another key factor in the pathogenesis of AS. The immune system, which normally defends the body against infections and foreign substances, malfunctions in individuals with AS. This leads to chronic inflammation and the production of inflammatory cytokines, which contribute to the symptoms and progression of the disease.
Environmental triggers, such as certain infections or traumatic events, are also believed to play a role in the development of AS. However, the exact mechanisms by which these triggers initiate or contribute to the disease process are not yet fully understood and require further research.
How RINVOQ Can Help Treat Ankylosing Spondylitis
RINVOQ (upadacitinib) is a prescription medication used to treat adults with moderately to severely active ankylosing spondylitis (AS).2 It belongs to a class of medications known as Janus kinase (JAK) inhibitors, which work by blocking the action of certain enzymes involved in the inflammatory process.
RINVOQ has been shown to be effective in reducing the signs and symptoms of AS, including pain, stiffness, and inflammation. It can also help improve physical function and quality of life in individuals with AS. RINVOQ is typically taken orally once daily, with or without food.
The safety and efficacy of RINVOQ have been evaluated in several clinical trials involving individuals with AS. These trials demonstrated that RINVOQ was effective in reducing disease activity, improving physical function, and reducing pain and stiffness. RINVOQwas also well-tolerated, with the most common side effects including upper respiratory tract infections, nausea, and headache.
Learn More About Ankylosing Spondylitis
For more information about ankylosing spondylitis (AS), including its symptoms, diagnosis, and treatment options, individuals can consult with a healthcare professional or visit reputable medical websites and resources. Some credible sources for information on AS include the following:
-
- The Spondylitis Association of America (SAA)
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- The Arthritis Foundation