Discover Cosentyx, a treatment option for ankylosing spondylitis (AS), a chronic inflammatory condition affecting the spine and joints. Learn how Cosentyx can alleviate AS symptoms and improve quality of life.
What is Ankylosing Spondylitis?
Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints, which connect the spine to the pelvis.1 It is a type of inflammatory arthritis that belongs to a group of conditions known as spondyloarthritis. AS is characterized by inflammation of the joints and ligaments of the spine, leading to stiffness, pain, and reduced mobility. In severe cases, it can cause the vertebrae to fuse together, resulting in a hunched posture and limited spinal movement.
AS typically begins in early adulthood, with symptoms often appearing between the ages of 20 and 40. It is more prevalent in males than females, and certain genetic factors, such as the presence of the HLA-B27 gene, are associated with an increased risk of developing the condition. AS is a progressive disease, meaning that symptoms tend to worsen over time if left untreated.
The exact cause of AS is unknown, but it is believed to involve a combination of genetic, environmental, and immunological factors. It is thought that the immune system mistakenly attacks the joints and ligaments of the spine, leading to inflammation and damage. AS is often associated with other autoimmune conditions, such as inflammatory bowel disease and psoriasis.
Discover Ankylosing Spondylitis Symptoms and Treatment
The most common symptom of AS is chronic back pain and stiffness, particularly in the lower back and buttocks. The pain is often worse in the morning and improves with movement. Other symptoms may include fatigue, joint pain in other areas of the body, such as the hips, shoulders, or knees, and inflammation of the eyes (uveitis). In severe cases, AS can lead to spinal deformities, such as a hunched posture (kyphosis) or a forward-leaning posture (flexion deformity).
The diagnosis of AS can be challenging, as there is no single test that can definitively confirm the condition. Doctors typically rely on a combination of factors, including a person’s symptoms, physical examination, imaging tests (such as X-rays or MRI scans), and blood tests to look for inflammation markers. Early diagnosis and treatment are crucial to slow the progression of the disease and prevent complications.
Treatment for AS typically involves a combination of medications, physical therapy, and lifestyle modifications. Medications may include nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain and inflammation, disease-modifying antirheumatic drugs (DMARDs) to slow the progression of the disease, and biologics, such as Cosentyx, which target specific inflammatory pathways.
How Cosentyx Can Help Treat Ankylosing Spondylitis
Cosentyx (secukinumab) is a biologic medication used to treat AS.2 It is a fully human monoclonal antibody that targets interleukin-17A (IL-17A), a cytokine that plays a crucial role in the inflammatory process of AS. By blocking IL-17A, Cosentyx helps to reduce inflammation and improve symptoms in people with AS.
Cosentyx is administered as a subcutaneous injection, typically once a month. It has been shown to be effective in reducing pain, stiffness, and inflammation in people with AS. In clinical trials, Cosentyx significantly improved spinal mobility and reduced the risk of disease progression. Additionally, Cosentyx has been found to improve physical function and quality of life in people with AS.
Cosentyx is generally well-tolerated, with the most common side effects being injection site reactions, upper respiratory tract infections, and headaches. However, it is important to note that Cosentyx may increase the risk of serious infections, so it is crucial to follow the dosing and administration instructions provided by a healthcare professional.
Learn More About Ankylosing Spondylitis
For more information about AS, including symptoms, diagnosis, treatment options, and managing the condition, individuals can consult with a healthcare professional or visit reputable sources such as the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) or the Spondylitis Association of America (SAA). These organizations provide comprehensive resources and support for individuals affected by AS.